RHEB

Across TCGA cell cohorts, RHEB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,933 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHEB-associated GO terms across cancer lineages are Peptidyl-glutamic acid carboxylation, Protein carboxylation, and Negative regulation of synaptic vesicle exocytosis. Each is linked with RHEB in more than 11 cancer types. Because this analysis shows association rather than direction, both RHEB-to-partner and partner-to-RHEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamic acid carboxylation grouped by RHEB-low versus RHEB-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEB→partner) and Y-score (partner→RHEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Peptidyl-glutamic acid carboxylation →	+0.086	+0.587	.009	.007	3	12
LUNG_NSCLC_LUAD	Protein carboxylation →	+0.086	+0.587	.009	.007	3	12
BREAST	Negative regulation of synaptic vesicle exocytosis →	+0.143	+0.895	<.001	.003	3	12
BREAST	Endoplasmic reticulum-plasma membrane tethering →	+0.184	+1.156	<.001	<.001	3	12
OVARY	Negative regulation of calcium ion-dependent exocytosis →	+0.129	+0.938	<.001	<.001	3	10
BREAST	Regulation of telomeric D-loop disassembly →	+0.098	+0.908	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,933 associations by consensus.

Peptidyl-glutamic acid carboxylation by RHEB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →