RHCG

Across TCGA patient cohorts, RHCG mutation is significantly associated with the RNA expression of many other genes, with 1,542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHCG-associated genes across cancer lineages are NDOR1, NTMT1, and MIGA2. Each is linked with RHCG in more than 2 cancer types. Because this analysis shows association rather than direction, both RHCG-to-partner and partner-to-RHCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDOR1 grouped by RHCG-low versus RHCG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHCG→partner) and Y-score (partner→RHCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDOR1 →	+0.451	+2.180	.001	.009	3	3
UCEC	NTMT1 →	+0.514	+2.321	.002	.001	3	3
UCEC	MIGA2 →	+0.321	+1.938	.002	.008	3	3
CESC	MIR6765 →	+0.442	+5.786	<.001	<.001	3	3
UCEC	CDT1 →	+0.723	+1.958	<.001	.003	3	3
UCS	NDFIP2-AS1 →	+0.132	+5.087	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,542 associations by consensus.

NDOR1 by RHCG expression — UCEC

Explore this box plot interactively →