RHBG

Across TCGA patient cohorts, RHBG mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBG-associated genes across cancer lineages are PCNA, ATM, and p62 Lck ligand. Each is linked with RHBG in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBG-to-partner and partner-to-RHBG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RHBG-low versus RHBG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBG→partner) and Y-score (partner→RHBG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.271	+3.321	.007	.009	3	2
UCEC	ATM →	-0.666	-3.308	.001	.009	3	2
UCEC	p62 Lck ligand →	+0.491	+3.331	.001	.005	3	1
UCEC	Annexin-1 →	+0.869	+3.479	<.001	.002	3	1
UCEC	STAT3_pY705 →	-0.393	-2.311	.001	.034	3	1
UCEC	Bax →	+0.255	+2.817	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PCNA by RHBG expression — UCEC

Explore this box plot interactively →