RHBDL1

Across TCGA cell cohorts, RHBDL1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHBDL1-associated genes across cancer lineages are TSHB, CRYAA, and CTRB2. Each is linked with RHBDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDL1-to-partner and partner-to-RHBDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by RHBDL1-low versus RHBDL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL1→partner) and Y-score (partner→RHBDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSHB →	+0.140	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	CRYAA →	+0.044	+3.705	.007	.007	3	1
BLOOD_Leukemia	CTRB2 →	+0.110	+3.855	<.001	.007	3	1
BLOOD_Leukemia	SFT2D3 →	+0.780	+4.450	<.001	.001	3	1
BLOOD_Leukemia	TAS1R2 →	+0.015	+3.855	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.619	+4.691	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TSHB by RHBDL1 expression — BLOOD_Leukemia

Explore this box plot interactively →