RHBDL1

Across TCGA pan-cancer cohorts, RHBDL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RHBDL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RHBDL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHBDL1 is over-expressed in tumor.

COAD, HNSC, and LUAD are the cancer types where RHBDL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHBDL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.463	<.001	10	view →
HNSC	Male	All	+1.062	<.001	10	view →
LUAD	Female	III,IV	+2.449	<.001	9	view →
LIHC	All	II,III,IV	+1.336	<.001	9	view →
THCA	Female	All	+0.372	<.001	9	view →
KIRC	Male	II,III,IV	+0.856	<.001	8	view →
UCEC	All	All	+1.497	<.001	6	view →
LUSC	Female	All	+1.349	<.001	6	view →
BRCA	All	III,IV	+1.138	<.001	6	view →
CHOL	Male	All	+2.110	<.001	5	view →
PAAD	All	All	+2.050	.008	2	view →
READ	All	II,III,IV	+1.082	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RHBDL1–COAD

Open the COAD breakdown →