RGSL1

Across TCGA patient cohorts, RGSL1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGSL1-associated genes across cancer lineages are ERK2, eEF2, and EGFR_pY1068. Each is linked with RGSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGSL1-to-partner and partner-to-RGSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RGSL1-low versus RGSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGSL1→partner) and Y-score (partner→RGSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.236	+2.169	<.001	<.001	3	3
UCEC	eEF2 →	+0.269	+1.700	.015	.040	3	2
UCEC	EGFR_pY1068 →	-0.230	-1.643	.003	.003	3	2
UCEC	MEK1 →	+0.247	+1.662	.030	.010	3	2
UCEC	Shc_pY317 →	-0.118	-1.415	.012	.010	3	2
UCEC	ASNS →	+0.353	+1.321	.001	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by RGSL1 expression — UCEC

Explore this box plot interactively →