RGSL1

Across TCGA pan-cancer cohorts, RGSL1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RGSL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGSL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGSL1 is over-expressed in tumor, although a few such as CHOL and COAD show the opposite, repressed pattern.

KIRC, LIHC, and LUSC are the cancer types where RGSL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGSL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.020	<.001	11	view →
LIHC	Male	All	+0.732	.004	4	view →
LUSC	Male	All	+0.064	<.001	4	view →
CHOL	Male	All	−0.056	.002	2	view →
PAAD	Male	All	+0.024	.037	2	view →
COAD	Female	III,IV	−0.012	.012	1	view →
THCA	All	IV	+0.007	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RGSL1–KIRC

Open the KIRC breakdown →