RGSL1

Across TCGA cell cohorts, RGSL1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RGSL1-associated genes across cancer lineages are MBD3L1, CPN1, and OR51I2. Each is linked with RGSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGSL1-to-partner and partner-to-RGSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L1 grouped by RGSL1-low versus RGSL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGSL1→partner) and Y-score (partner→RGSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MBD3L1 →	+0.025	+3.169	<.001	.007	3	2
BREAST	CPN1 →	+0.987	+3.691	<.001	.009	3	2
BREAST	OR51I2 →	+0.087	+4.232	<.001	.002	3	2
BLOOD_Lymphoma	WFDC8 →	+0.022	+4.867	<.001	.009	3	2
BLOOD_Lymphoma	TEX43 →	+0.094	+5.643	<.001	.002	3	2
BONE	OR4A47 →	+0.005	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MBD3L1 by RGSL1 expression — SOFT_TISSUE

Explore this box plot interactively →