RGS8

Across TCGA pan-cancer cohorts, RGS8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RGS8 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RGS8 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated RGS8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, COAD, and UCEC are the cancer types where RGS8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	1.000	0.685	.017	11	view →
COAD	OS	Median	II,III,IV	0.111	0.851	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.636	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RGS8–SKCM (OS)

Open the SKCM breakdown →