RGS8

Across TCGA pan-cancer cohorts, RGS8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RGS8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RGS8 RNA is repressed in tumor relative to normal tissue. In most cancer types RGS8 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where RGS8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.571	<.001	11	view →
KICH	All	All	+0.660	<.001	8	view →
BRCA	All	II,III,IV	+0.190	<.001	8	view →
KIRC	Male	II,III,IV	−0.109	<.001	8	view →
KIRP	Female	All	−0.096	<.001	7	view →
COAD	All	All	−0.020	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RGS8–THCA

Open the THCA breakdown →