RGS8

Across TCGA patient cohorts, RGS8 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS8-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and MSH2. Each is linked with RGS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS8-to-partner and partner-to-RGS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RGS8-low versus RGS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS8→partner) and Y-score (partner→RGS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.241	-2.459	.047	.020	3	1
UCEC	A-Raf_pS299 →	-0.122	-2.459	.034	.020	3	1
UCEC	MSH2 →	-0.303	-2.459	.006	.020	3	1
UCEC	Notch1 →	+0.246	+2.335	<.001	.018	3	1
UCEC	PKC-delta_pS664 →	-0.160	-2.459	.005	.020	3	1
UCEC	Annexin-1 →	+0.558	+2.999	.028	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by RGS8 expression — UCEC

Explore this box plot interactively →