RGS8

Across TCGA cell cohorts, RGS8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,772 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RGS8-associated GO terms across cancer lineages are Angiotensin-activated signaling pathway, tRNA transcription by RNA polymerase III, and Regulation of DNA repair. Each is linked with RGS8 in more than 5 cancer types. Because this analysis shows association rather than direction, both RGS8-to-partner and partner-to-RGS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Angiotensin-activated signaling pathway grouped by RGS8-low versus RGS8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS8→partner) and Y-score (partner→RGS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Angiotensin-activated signaling pathway →	-0.210	-0.288	<.001	.006	3	5
LUNG_SCLC	tRNA transcription by RNA polymerase III →	+0.112	+2.017	<.001	<.001	3	5
SOFT_TISSUE	Regulation of DNA repair →	+0.050	+0.309	<.001	.003	3	5
LUNG_SCLC	Cytoplasmic microtubule organization →	+0.058	+1.582	<.001	.004	2	6
LUNG_SCLC	Stress granule assembly →	+0.109	+2.320	<.001	<.001	3	5
LUNG_SCLC	DNA damage checkpoint signaling →	+0.042	+1.632	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,772 associations by consensus.

Angiotensin-activated signaling pathway by RGS8 expression — SOFT_TISSUE

Explore this box plot interactively →