RGS7

Across TCGA cell cohorts, RGS7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,305 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RGS7-associated GO terms across cancer lineages are Negative regulation of post-translational protein modification, Regulation of protein K48-linked ubiquitination, and Negative regulation of protein modification by small protein conjugation or removal. Each is linked with RGS7 in more than 7 cancer types. Because this analysis shows association rather than direction, both RGS7-to-partner and partner-to-RGS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of post-translational protein modification grouped by RGS7-low versus RGS7-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS7→partner) and Y-score (partner→RGS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of post-translational protein modification →	+0.080	+1.163	<.001	.001	3	8
CNS	Regulation of protein K48-linked ubiquitination →	+0.102	+0.968	<.001	<.001	3	8
OVARY	Negative regulation of protein modification by small protein conjugation or removal →	+0.087	+1.181	<.001	.002	3	8
SOFT_TISSUE	Negative regulation of protein modification process →	+0.042	+0.887	.003	.002	3	7
OVARY	Negative regulation of protein ubiquitination →	+0.088	+1.058	<.001	.001	3	7
SKIN	Phenol-containing compound metabolic process →	-0.251	-0.972	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,305 associations by consensus.

Negative regulation of post-translational protein modification by RGS7 expression — OVARY

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