RGS7

Across TCGA pan-cancer cohorts, RGS7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RGS7 data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RGS7 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RGS7 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

BRCA, PAAD, and UCS are the cancer types where RGS7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	II,III,IV	0.971	0.909	<.001	85	view →
PAAD	DFS	Quartile	All	0.457	0.141	<.001	70	view →
UCS	DFS	Median	II,III,IV	0.593	0.131	<.001	68	view →
LIHC	DFS	Tertile	All	0.215	0.336	<.001	67	view →
READ	OS	Tertile	All	0.689	0.888	.002	66	view →
MESO	DFS	Median	II,III,IV	0.279	0.519	<.001	60	view →
UVM	DFS	Quartile	All	0.430	0.799	.001	38	view →
CESC	DFS	Tertile	IV	0.855	0.327	.017	36	view →
KIRP	DFS	Tertile	All	1.000	0.527	.001	26	view →
LUSC	OS	Median	II,III,IV	0.303	0.507	.003	21	view →
LGG	DFS	Median	All	0.480	0.298	.002	20	view →
GBM	OS	Quartile	All	0.341	0.527	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RGS7–BRCA (DFS)

Open the BRCA breakdown →