RGS7

Across TCGA cell cohorts, RGS7 mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RGS7-associated genes across cancer lineages are GRIFIN, GRM6, and OR52A1. Each is linked with RGS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS7-to-partner and partner-to-RGS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by RGS7-low versus RGS7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS7→partner) and Y-score (partner→RGS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GRIFIN →	+0.117	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	GRM6 →	+0.275	+3.562	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR52A1 →	+0.021	+3.343	.004	.005	3	1
LUNG_NSCLC_LUAD	DEFB108B →	+0.119	+3.786	.001	.001	3	1
LUNG_NSCLC_LUAD	TAS2R41 →	+0.054	+3.481	<.001	.004	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.015	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

GRIFIN by RGS7 expression — LUNG_SCLC

Explore this box plot interactively →