RGS5

Across TCGA patient cohorts, RGS5 mutation is significantly associated with the RNA expression of many other genes, with 1,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS5-associated genes across cancer lineages are EIF3J, OAZ1, and RRP9. Each is linked with RGS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS5-to-partner and partner-to-RGS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3J grouped by RGS5-low versus RGS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS5→partner) and Y-score (partner→RGS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3J →	+0.567	+2.584	<.001	.001	3	2
UCEC	OAZ1 →	+0.584	+2.660	<.001	<.001	3	2
UCEC	RRP9 →	+0.374	+2.108	.008	.003	3	2
UCEC	MRPL19 →	+0.567	+2.584	.001	.001	3	2
UCEC	NOL10 →	+0.441	+3.617	.002	.001	3	2
UCEC	WRAP73 →	+0.349	+3.502	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,212 associations by consensus.

EIF3J by RGS5 expression — UCEC

Explore this box plot interactively →