RGS5

Across TCGA pan-cancer cohorts, RGS5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RGS5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGS5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGS5 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

KIRC, BLCA, and LIHC are the cancer types where RGS5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.837	<.001	12	view →
BLCA	Male	III,IV	−3.417	<.001	11	view →
LIHC	Male	III,IV	+2.354	<.001	9	view →
LUSC	Female	All	−2.278	<.001	8	view →
LUAD	Female	III,IV	−1.716	<.001	7	view →
KICH	All	All	−0.980	.002	7	view →
UCEC	All	All	−2.359	<.001	6	view →
KIRP	Male	All	−1.640	<.001	5	view →
COAD	All	All	−0.771	.005	5	view →
BRCA	All	All	−0.782	<.001	4	view →
CHOL	All	All	+2.073	<.001	3	view →
HNSC	Female	III,IV	+1.262	.015	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RGS5–KIRC

Open the KIRC breakdown →