RGS3

Across TCGA pan-cancer cohorts, RGS3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RGS3 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RGS3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RGS3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LSCC, CCRCC, and UCEC are the cancer types where RGS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.531	0.929	.009	20	view →
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	16	view →
UCEC	OS	Median	All	1.000	0.903	.006	14	view →
PDAC	DFS	Tertile	All	0.436	0.275	.024	9	view →
HNSC	OS	Quartile	III,IV	0.782	0.987	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RGS3–LSCC (OS)

Open the LSCC breakdown →