RGS3

Across TCGA pan-cancer cohorts, RGS3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RGS3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RGS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGS3 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, LUSC, and KICH are the cancer types where RGS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.193	<.001	12	view →
LUSC	Male	II,III,IV	−1.241	<.001	8	view →
KICH	Female	II,III,IV	−1.457	<.001	7	view →
THCA	Male	All	+0.568	<.001	7	view →
STAD	Male	II,III,IV	+0.933	.001	5	view →
BRCA	All	All	−0.264	.001	4	view →
CHOL	All	All	+1.794	<.001	3	view →
COAD	All	IV	+0.384	.002	3	view →
ESCA	All	All	+1.093	.004	2	view →
LIHC	Female	All	+0.527	.012	2	view →
KIRC	All	II,III,IV	−0.307	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RGS3–HNSC

Open the HNSC breakdown →