RGS3

Across TCGA patient cohorts, RGS3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,930 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RGS3-associated genes across cancer lineages are FAS, IL21R, and PTPN22. Each is linked with RGS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both RGS3-to-partner and partner-to-RGS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RGS3 versus FAS in GBM, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS3→partner) and Y-score (partner→RGS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAS →	+0.737	+0.363	<.001	<.001	3	6
BRCA	IL21R →	+0.827	+0.387	<.001	<.001	3	6
LUAD	PTPN22 →	+0.819	+0.301	<.001	<.001	3	6
LSCC	LGALS9 →	+0.816	+0.324	<.001	<.001	3	6
LUAD	TUSC3 →	-1.131	-0.312	.002	.001	3	5
LUAD	CORO2A →	+0.762	+0.274	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,930 associations by consensus.

RGS3 vs FAS — GBM

Explore this scatter interactively →