RGS3

Across TCGA patient cohorts, RGS3 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS3-associated genes across cancer lineages are Rb_pS807_S811, 14-3-3_beta, and eEF2. Each is linked with RGS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS3-to-partner and partner-to-RGS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb_pS807_S811 grouped by RGS3-low versus RGS3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS3→partner) and Y-score (partner→RGS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Rb_pS807_S811 →	+0.548	+3.009	.015	.019	3	3
UCEC	14-3-3_beta →	-0.093	-3.221	.001	<.001	3	3
UCEC	eEF2 →	+0.359	+2.999	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.201	-2.736	<.001	<.001	3	3
UCEC	p53 →	-0.258	-1.321	.021	.027	3	3
UCEC	PKC-delta_pS664 →	-0.080	-1.415	.021	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Rb_pS807_S811 by RGS3 expression — LUSC

Explore this box plot interactively →