RGS3

Across TCGA cell cohorts, RGS3 mutation is significantly associated with the RNA expression of many other genes, with 565 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS3-associated genes across cancer lineages are CENPM, PHF5A, and TTK. Each is linked with RGS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS3-to-partner and partner-to-RGS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by RGS3-low versus RGS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS3→partner) and Y-score (partner→RGS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPM →	+0.647	+3.321	.002	.003	3	2
LARGE_INTESTINE	PHF5A →	+0.523	+3.257	<.001	.002	3	2
LARGE_INTESTINE	TTK →	+0.490	+1.850	.004	.006	3	2
LARGE_INTESTINE	C12orf29 →	+0.502	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	USP1 →	+0.628	+2.451	<.001	<.001	3	2
LARGE_INTESTINE	CCDC138 →	+0.527	+1.850	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 565 associations by consensus.

CENPM by RGS3 expression — LARGE_INTESTINE

Explore this box plot interactively →