RGS21

Across TCGA cell cohorts, RGS21 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RGS21-associated genes across cancer lineages are KRTAP6-1, MDFIC2, and CD300H. Each is linked with RGS21 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS21-to-partner and partner-to-RGS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by RGS21-low versus RGS21-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS21→partner) and Y-score (partner→RGS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP6-1 →	+0.100	+6.022	<.001	.001	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
CNS	RNASE11 →	+0.034	+5.321	<.001	.005	3	1
CNS	OR56A1 →	+0.013	+6.357	<.001	<.001	3	1
CNS	OR52L1 →	+0.062	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRTAP6-1 by RGS21 expression — SKIN

Explore this box plot interactively →