RGS21

Across TCGA pan-cancer cohorts, RGS21 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated RGS21 data layer compared with 6 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher RGS21 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RGS21 expression acts as an unfavorable survival marker, although some lineages such as THYM show a favorable association.

THCA, LUAD, and SKCM are the cancer types where RGS21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	IV	0.095	0.966	<.001	75	view →
LUAD	OS	Tertile	III,IV	0.298	0.705	.001	39	view →
SKCM	OS	Tertile	III,IV	0.375	0.716	.004	36	view →
LGG	OS	Tertile	All	0.731	0.921	.002	30	view →
ACC	DFS	Tertile	All	0.448	0.686	.029	27	view →
UCS	OS	Tertile	IV	0.225	0.569	.041	18	view →
PAAD	OS	Tertile	II,III,IV	0.356	0.569	.040	9	view →
SARC	OS	Tertile	All	0.399	0.624	.021	9	view →
THYM	DFS	Quartile	All	0.965	0.826	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RGS21–THCA (OS)

Open the THCA breakdown →