RGS20

Across TCGA cell cohorts, RGS20 mutation is significantly associated with the RNA expression of many other genes, with 124 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS20-associated genes across cancer lineages are ADAM2, OR1Q1, and OR51Q1. Each is linked with RGS20 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS20-to-partner and partner-to-RGS20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by RGS20-low versus RGS20-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS20→partner) and Y-score (partner→RGS20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM2 →	+0.046	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR1Q1 →	+0.058	+3.760	.007	.008	3	1
LUNG_NSCLC_LUAD	OR51Q1 →	+0.180	+3.866	<.001	.006	3	1
LUNG_NSCLC_LUAD	KIR2DS4 →	+0.261	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	CT47A6 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	MYH4 →	+0.007	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 124 associations by consensus.

ADAM2 by RGS20 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →