RGS14

Across TCGA pan-cancer cohorts, RGS14 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RGS14 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher RGS14 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RGS14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, LIHC, and UCEC are the cancer types where RGS14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
LIHC	DFS	Median	II,III,IV	0.053	0.427	.003	9	view →
UCEC	DFS	Median	II,III,IV	1.000	0.486	.032	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RGS14–SCLC (DFS)

Open the SCLC breakdown →