RGS12

Across TCGA cell cohorts, RGS12 mutation is significantly associated with the RNA expression of many other genes, with 1,821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS12-associated genes across cancer lineages are TEX53, RNMT, and ADAMTS17. Each is linked with RGS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS12-to-partner and partner-to-RGS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX53 grouped by RGS12-low versus RGS12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS12→partner) and Y-score (partner→RGS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TEX53 →	+0.095	+3.347	<.001	.005	3	2
LARGE_INTESTINE	RNMT →	+0.527	+2.331	.003	.001	3	2
BLOOD_Leukemia	ADAMTS17 →	+1.990	+3.199	<.001	.007	3	2
BLOOD_Leukemia	ZNF711 →	+2.076	+3.199	.001	.007	3	2
BLOOD_Leukemia	GKAP1 →	+1.329	+3.260	<.001	.005	3	2
BLOOD_Leukemia	RNF152 →	+0.606	+3.199	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,821 associations by consensus.

TEX53 by RGS12 expression — SKIN

Explore this box plot interactively →