RGS12

Across TCGA pan-cancer cohorts, RGS12 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RGS12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RGS12 RNA is repressed in tumor relative to normal tissue. In most cancer types RGS12 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where RGS12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.188	<.001	11	view →
KIRC	Male	IV	+0.987	<.001	11	view →
COAD	Female	All	+0.524	<.001	10	view →
LIHC	Female	II,III,IV	+1.100	<.001	9	view →
LUAD	Female	II,III,IV	−0.703	<.001	6	view →
KIRP	All	All	+0.537	.003	4	view →
BRCA	Female	All	−0.278	.001	4	view →
CHOL	All	All	+1.184	<.001	3	view →
PRAD	All	All	−0.450	<.001	2	view →
LUSC	All	All	+0.331	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RGS12–KICH

Open the KICH breakdown →