RGS11

Across TCGA patient cohorts, RGS11 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS11-associated genes across cancer lineages are Chk2_pT68, JNK_pT183_Y185, and Lck. Each is linked with RGS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS11-to-partner and partner-to-RGS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by RGS11-low versus RGS11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS11→partner) and Y-score (partner→RGS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk2_pT68 →	+0.240	+2.820	.007	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.216	-2.986	.026	.037	3	1
UCEC	Lck →	+0.313	+3.000	.006	.037	3	1
UCEC	N-Ras →	-0.193	-2.986	.005	.037	3	1
UCEC	p62 Lck ligand →	+0.422	+3.000	.025	.037	3	1
UCEC	SCD →	-0.176	-2.986	.005	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Chk2_pT68 by RGS11 expression — SKCM

Explore this box plot interactively →