RGS1

Across TCGA pan-cancer cohorts, RGS1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RGS1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RGS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RGS1 expression acts as an unfavorable survival marker.

HNSC, LSCC, and LUAD are the cancer types where RGS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.224	1.000	.036	4	view →
LSCC	DFS	Tertile	II,III,IV	0.564	1.000	.030	4	view →
LUAD	OS	Median	All	0.701	0.975	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RGS1–HNSC (OS)

Open the HNSC breakdown →