RGPD8

Across TCGA pan-cancer cohorts, RGPD8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RGPD8 data layer compared with 14 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RGPD8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RGPD8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, STAD, and LIHC are the cancer types where RGPD8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.614	.001	36	view →
STAD	DFS	Median	II,III,IV	1.000	0.335	.029	17	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	12	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RGPD8–UCEC (DFS)

Open the UCEC breakdown →