RGPD8

Across TCGA pan-cancer cohorts, RGPD8 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RGPD8’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RGPD8 RNA is repressed in tumor relative to normal tissue. In most cancer types RGPD8 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and THCA are the cancer types where RGPD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGPD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.391	<.001	6	view →
KICH	Female	All	−0.306	<.001	5	view →
THCA	All	All	−0.218	<.001	4	view →
LUSC	All	All	−0.178	<.001	4	view →
LUAD	Female	II,III,IV	−0.244	.009	2	view →
UCEC	All	All	−0.202	.014	2	view →
LIHC	Male	All	+0.181	.003	2	view →
HNSC	All	III,IV	+0.100	.041	2	view →
ESCA	Female	All	+0.453	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RGPD8–BRCA

Open the BRCA breakdown →