RGPD8

Across TCGA patient cohorts, RGPD8 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGPD8-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, EGFR_pY1068, and eIF4E. Each is linked with RGPD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGPD8-to-partner and partner-to-RGPD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by RGPD8-low versus RGPD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGPD8→partner) and Y-score (partner→RGPD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.362	+1.662	.043	.011	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.169	.001	.003	3	1
UCEC	eIF4E →	+0.209	+2.415	.004	.003	3	1
UCEC	ERK2 →	+0.138	+1.874	.043	.049	3	1
UCEC	FoxM1 →	+0.187	+1.362	.041	.037	3	1
UCEC	GATA6 →	-0.114	-2.307	.044	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Acetyl-a-Tubulin-Lys40 by RGPD8 expression — UCEC

Explore this box plot interactively →