RGP1

Across TCGA patient cohorts, RGP1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGP1-associated genes across cancer lineages are p27_pT198, ERK2, and p62 Lck ligand. Each is linked with RGP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGP1-to-partner and partner-to-RGP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by RGP1-low versus RGP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGP1→partner) and Y-score (partner→RGP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.114	+3.321	.041	.010	3	2
UCEC	ERK2 →	+0.201	+3.000	.047	.036	3	1
UCEC	p62 Lck ligand →	+0.340	+2.817	.046	.036	3	1
UCEC	SLC1A5 →	-0.580	-3.000	.013	.035	2	2
UCEC	STAT3_pY705 →	-0.634	-3.321	<.001	.009	3	1
UCEC	INPP4B →	-0.416	-3.169	.014	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p27_pT198 by RGP1 expression — UCEC

Explore this box plot interactively →