RGP1

Across TCGA pan-cancer cohorts, RGP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RGP1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RGP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGP1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

LIHC, COAD, and THCA are the cancer types where RGP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.500	<.001	9	view →
COAD	Female	II,III,IV	−0.778	<.001	9	view →
THCA	Male	II,III,IV	−0.753	<.001	9	view →
HNSC	All	III,IV	+0.726	<.001	9	view →
KIRC	Male	II,III,IV	−0.551	<.001	7	view →
BRCA	Female	All	−0.332	<.001	6	view →
CHOL	All	All	+2.171	<.001	5	view →
STAD	Male	IV	+0.785	.017	4	view →
LUAD	All	All	−0.302	.008	4	view →
BLCA	All	IV	−0.744	.032	2	view →
READ	All	All	−0.663	.007	2	view →
UCEC	All	All	−0.586	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RGP1–LIHC

Open the LIHC breakdown →