RGMB

Across TCGA patient cohorts, RGMB mutation is significantly associated with the RNA expression of many other genes, with 1,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGMB-associated genes across cancer lineages are MIR4293, GIMAP7, and VWA1. Each is linked with RGMB in more than 1 cancer types. Because this analysis shows association rather than direction, both RGMB-to-partner and partner-to-RGMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4293 grouped by RGMB-low versus RGMB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMB→partner) and Y-score (partner→RGMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4293 →	+0.414	+9.057	<.001	.003	3	1
UCEC	GIMAP7 →	+0.743	+3.329	.005	.005	3	1
UCEC	VWA1 →	-1.143	-3.785	<.001	<.001	3	1
UCEC	C14orf28 →	+0.407	+2.332	.001	.003	3	1
UCEC	AKAP5 →	+0.428	+3.000	.004	.001	3	1
UCEC	TMEM150B →	+0.735	+3.467	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,037 associations by consensus.

MIR4293 by RGMB expression — BRCA

Explore this box plot interactively →