RGMB-AS1

Across TCGA pan-cancer cohorts, RGMB-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RGMB-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RGMB-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RGMB-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and LIHC show a favorable association.

UVM, OV, and LIHC are the cancer types where RGMB-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.330	0.821	<.001	95	view →
OV	OS	Median	III,IV	0.890	0.781	.001	68	view →
LIHC	DFS	Median	II,III,IV	0.436	0.218	<.001	47	view →
PAAD	OS	Quartile	All	0.576	0.229	<.001	44	view →
LGG	DFS	Median	All	0.492	0.275	<.001	40	view →
READ	DFS	Tertile	All	0.934	0.768	.001	31	view →
ESCA	OS	Median	All	0.647	1.000	.015	18	view →
UCS	DFS	Tertile	IV	0.978	0.298	.024	18	view →
HNSC	OS	Quartile	III,IV	0.352	0.767	<.001	17	view →
KIRC	DFS	Quartile	II,III,IV	0.376	0.638	.012	16	view →
BLCA	OS	Quartile	II,III,IV	0.798	0.655	.019	15	view →
THCA	DFS	Median	All	0.960	0.909	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

RGMB-AS1–UVM (DFS)

Open the UVM breakdown →