RGMA

Across TCGA patient cohorts, RGMA mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGMA-associated genes across cancer lineages are eEF2, Annexin-1, and ATM. Each is linked with RGMA in more than 1 cancer types. Because this analysis shows association rather than direction, both RGMA-to-partner and partner-to-RGMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RGMA-low versus RGMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMA→partner) and Y-score (partner→RGMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.343	+1.662	.006	.011	3	2
UCEC	Annexin-1 →	+0.580	+1.827	.001	.015	3	2
UCEC	ATM →	-0.537	-2.687	<.001	.005	3	2
SKCM	Bid →	+0.248	+3.000	.004	.035	3	2
UCEC	EGFR_pY1068 →	-0.260	-2.321	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.139	-1.807	<.001	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by RGMA expression — UCEC

Explore this box plot interactively →