RGMA

Across TCGA pan-cancer cohorts, RGMA RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RGMA data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RGMA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RGMA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

HNSC, BLCA, and LUSC are the cancer types where RGMA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.768	0.599	<.001	116	view →
BLCA	OS	Median	All	0.332	0.527	<.001	86	view →
LUSC	OS	Quartile	All	0.765	0.573	<.001	53	view →
UCS	DFS	Quartile	II,III,IV	0.698	0.145	.002	40	view →
UCEC	DFS	Median	IV	0.672	0.259	.003	36	view →
KIRP	DFS	Tertile	All	0.855	0.974	<.001	32	view →
LUAD	OS	Median	II,III,IV	0.771	0.644	.004	30	view →
SARC	OS	Tertile	All	0.644	0.285	<.001	30	view →
ACC	DFS	Quartile	All	0.151	0.648	.001	27	view →
SKCM	DFS	Quartile	All	0.838	0.631	.006	23	view →
LIHC	DFS	Quartile	All	0.696	0.475	.005	22	view →
ESCA	OS	Median	II,III,IV	0.788	0.615	.013	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RGMA–HNSC (DFS)

Open the HNSC breakdown →