RGMA

Across TCGA cell cohorts, RGMA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,052 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RGMA-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Positive regulation of striated muscle contraction, and Negative regulation of hemostasis. Each is linked with RGMA in more than 11 cancer types. Because this analysis shows association rather than direction, both RGMA-to-partner and partner-to-RGMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by RGMA-low versus RGMA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMA→partner) and Y-score (partner→RGMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of mRNA metabolic process →	+0.085	+1.711	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Positive regulation of striated muscle contraction →	-0.231	-0.986	<.001	.003	3	11
SOFT_TISSUE	Negative regulation of hemostasis →	-0.195	-1.768	<.001	<.001	3	10
SOFT_TISSUE	Negative regulation of blood coagulation →	-0.195	-1.768	<.001	<.001	3	10
STOMACH	Regulation of DNA-templated transcription elongation →	+0.064	+0.583	<.001	.002	3	10
BREAST	U2-type prespliceosome assembly →	+0.102	+1.368	<.001	.009	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,052 associations by consensus.

Negative regulation of mRNA metabolic process by RGMA expression — LUNG_SCLC

Explore this box plot interactively →