RGMA

Across TCGA cell cohorts, RGMA mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGMA-associated genes across cancer lineages are TEX26, IQCF3, and KRTAP19-3. Each is linked with RGMA in more than 1 cancer types. Because this analysis shows association rather than direction, both RGMA-to-partner and partner-to-RGMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX26 grouped by RGMA-low versus RGMA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMA→partner) and Y-score (partner→RGMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TEX26 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.049	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.132	+5.228	<.001	.005	3	1
BLOOD_Leukemia	PRKAG3 →	+0.031	+3.381	<.001	.002	3	1
BLOOD_Leukemia	ODF1 →	+0.062	+3.266	<.001	.003	3	1
BLOOD_Leukemia	SLC2A2 →	+0.010	+3.556	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TEX26 by RGMA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →