RGL4

Across TCGA patient cohorts, RGL4 mutation is significantly associated with the RNA expression of many other genes, with 2,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL4-associated genes across cancer lineages are EEF1E1-BLOC1S5, LSM3P4, and MIR3661. Each is linked with RGL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both RGL4-to-partner and partner-to-RGL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by RGL4-low versus RGL4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL4→partner) and Y-score (partner→RGL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EEF1E1-BLOC1S5 →	+0.036	+2.388	<.001	.004	3	4
LIHC	LSM3P4 →	+0.162	+6.305	<.001	.001	3	3
UCEC	MIR3661 →	+0.570	+1.594	<.001	.004	3	3
READ	CDY3P →	+0.037	+6.276	<.001	<.001	3	2
READ	CYCSP22 →	+0.151	+4.421	<.001	.009	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,020 associations by consensus.

EEF1E1-BLOC1S5 by RGL4 expression — SKCM

Explore this box plot interactively →