RGL4

Across TCGA pan-cancer cohorts, RGL4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RGL4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGL4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGL4 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where RGL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.443	<.001	11	view →
KICH	All	All	+0.605	<.001	8	view →
LUSC	All	II,III,IV	−0.408	<.001	6	view →
BRCA	All	III,IV	−0.350	<.001	6	view →
COAD	All	All	−0.175	.004	6	view →
CHOL	All	All	+0.842	<.001	2	view →
LIHC	Female	II,III,IV	+0.164	.035	2	view →
LUAD	All	III,IV	−0.197	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RGL4–KIRC

Open the KIRC breakdown →