RGL4

Across TCGA patient cohorts, RGL4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL4-associated genes across cancer lineages are 14-3-3_beta, Rab25, and Di-Ras3. Each is linked with RGL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL4-to-partner and partner-to-RGL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RGL4-low versus RGL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL4→partner) and Y-score (partner→RGL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.123	-2.088	.001	.016	3	2
UCEC	Rab25 →	-0.388	-3.321	.002	.009	3	2
UCEC	Di-Ras3 →	-0.216	-2.571	<.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.185	-3.459	<.001	.005	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.443	+1.678	.006	.023	3	1
UCEC	JNK2 →	+0.241	+2.348	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

14-3-3_beta by RGL4 expression — UCEC

Explore this box plot interactively →