RGL4

Across TCGA cell cohorts, RGL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,341 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGL4-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Glycerolipid biosynthetic process. Each is linked with RGL4 in more than 13 cancer types. Because this analysis shows association rather than direction, both RGL4-to-partner and partner-to-RGL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by RGL4-low versus RGL4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL4→partner) and Y-score (partner→RGL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of DNA-templated transcription initiation →	+0.130	+0.243	<.001	<.001	3	14
BREAST	Negative regulation of transcription initiation by RNA polymerase II →	+0.130	+0.243	<.001	<.001	3	14
OESOPHAGUS	Glycerolipid biosynthetic process →	+0.061	+0.252	.002	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.099	-0.171	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.105	-0.171	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.130	-0.283	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,341 associations by consensus.

Negative regulation of DNA-templated transcription initiation by RGL4 expression — BREAST

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