RGL4

Across TCGA cell cohorts, RGL4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RGL4-associated genes across cancer lineages are GALNTL5, DEFB125, and OR52E8. Each is linked with RGL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGL4-to-partner and partner-to-RGL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by RGL4-low versus RGL4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL4→partner) and Y-score (partner→RGL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALNTL5 →	+0.021	+4.415	<.001	.007	3	1
SKIN	DEFB125 →	+0.044	+4.415	<.001	.007	3	1
SKIN	OR52E8 →	+0.027	+4.415	<.001	.007	3	1
SKIN	SCYGR10 →	+0.247	+4.684	<.001	.002	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GALNTL5 by RGL4 expression — SKIN

Explore this box plot interactively →