Across TCGA cell cohorts, RGL3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGL3-associated genes across cancer lineages are CLEC2A, SPATS1, and OR6B3. Each is linked with RGL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGL3-to-partner and partner-to-RGL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL3→partner) and Y-score (partner→RGL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLEC2A →	+0.733	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	SPATS1 →	+0.810	+4.714	<.001	.002	3	1
SKIN	OR6B3 →	+0.136	+6.022	<.001	.001	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+2.588	+2.518	<.001	.006	3	1
LARGE_INTESTINE	WSCD2 →	+0.098	+2.648	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

RGL3 survival (RNA) · tumor vs normal (RNA) · all RGL3 data types