RGL2

Across TCGA cell cohorts, RGL2 mutation is significantly associated with the RNA expression of many other genes, with 231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGL2-associated genes across cancer lineages are CCR8, SPACA1, and TRIM51. Each is linked with RGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGL2-to-partner and partner-to-RGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by RGL2-low versus RGL2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL2→partner) and Y-score (partner→RGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LUNG_SCLC	SPACA1 →	+0.017	+4.643	<.001	.004	3	1
LUNG_SCLC	TRIM51 →	+0.104	+5.169	<.001	<.001	3	1
LUNG_SCLC	OR2AK2 →	+0.150	+4.269	<.001	.005	3	1
LUNG_SCLC	OR2L3 →	+0.083	+4.523	<.001	.003	3	1
BLOOD_Leukemia	HABP2 →	+0.274	+3.007	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 231 associations by consensus.

CCR8 by RGL2 expression — SOFT_TISSUE

Explore this box plot interactively →