RFXANK

Across TCGA cell cohorts, RFXANK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,354 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RFXANK-associated GO terms across cancer lineages are Regulation of glycolytic process through fructose-6-phosphate, Negative regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of protein localization to chromatin. Each is linked with RFXANK in more than 9 cancer types. Because this analysis shows association rather than direction, both RFXANK-to-partner and partner-to-RFXANK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glycolytic process through fructose-6-phosphate grouped by RFXANK-low versus RFXANK-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFXANK→partner) and Y-score (partner→RFXANK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of glycolytic process through fructose-6-phosphate →	+0.141	+1.043	.009	<.001	2	10
LIVER	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.141	+1.043	.009	<.001	2	10
URINARY_TRACT	Negative regulation of protein localization to chromatin →	+0.151	+1.027	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Negative regulation of NLRP3 inflammasome complex assembly →	+0.089	+0.601	<.001	.002	3	8
SOFT_TISSUE	Regulation of cell fate commitment →	+0.111	+0.504	.001	.001	3	8
LUNG_SCLC	Positive regulation of enamel mineralization →	+0.270	+0.603	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,354 associations by consensus.

Regulation of glycolytic process through fructose-6-phosphate by RFXANK expression — LIVER

Explore this box plot interactively →