RFXANK

Across TCGA cell cohorts, RFXANK mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFXANK-associated genes across cancer lineages are CST8, METTL21C, and SCGB3A2. Each is linked with RFXANK in more than 1 cancer types. Because this analysis shows association rather than direction, both RFXANK-to-partner and partner-to-RFXANK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by RFXANK-low versus RFXANK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFXANK→partner) and Y-score (partner→RFXANK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	METTL21C →	+0.155	+4.273	<.001	.006	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.379	+4.095	.001	.009	3	1
LARGE_INTESTINE	FAM71B →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PATE1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR2K2 →	+0.037	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CST8 by RFXANK expression — LARGE_INTESTINE

Explore this box plot interactively →